Nrf1, serving as a Highly-Conserved Determinon for Robust Redox Homeostasis
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Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories
Published in the journal Cell Stress. 2025 Jul 7:9:65-142. doi: 10.15698/cst2025.07.306. eCollection 2025.
PMID: 40703332 PMCID: PMC12285602 DOI: 10.15698/cst2025.07.306
Abstract
Differential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by Nfe2l1 and Nfe2l2, respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning, proteolytic processing, and biochemical modification, as well as in their shared evolutionary origin. As a matter of fact, the allelopathic potentials of Nrf1 and Nrf2 (both resembling two entangled 'Yin-Yang' quanta that comply with a dialectic law of the unity of opposites) are fulfilled to coordinately control redox physiological homeostasis so as to be maintained within the presetting thresholds. By putative exponential curves