Comparative Genomic Analysis of Mycobacterium Tuberculosis Complex Strains from Ghana
€ 64.5
描述
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTBC) has plagued mankind since recorded history and remains the leading cause of adult mortality globally yet treatable. Human TB is mainly caused by the globally distributed M. tuberculosis sensu stricto (Mtbss) and West Africa restricted M. africanum (Maf), but most global efforts for TB control largely concentrate on Mtbss. The reportedly high genetic homology of the MTBC and the observed relative attenuation of Maf compared to Mtbss have contributed to this neglect. However, Maf remains an important pathogen in West Africa especially Ghana (harbouring the two lineages (L) 5 and 6 in substantial numbers) where it causes about 20% of TB.