Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-kB activation
€ 36.5
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描述
Pathways LXRs-NF-kB-iNOS expression play a crucial role in proceeding metabolic abnormalities like atherosclerosis, obesity, inflammation, etc. Stigmast-4-en-3-one, with structure closely similar to cholesterol, acted selectively on LXRs but not on NFkB activation pathway. This suggests that it can be potentially applied as an agonist on LXR signalling pathway. Thus, the findings showed that dammarane-type triterpenoids from D. tpongense are worthy of further investigation for potential LXR agonists and potent anti-atherogenic agents against atherosclerotic lesion progression.